By using human biological samples (blood, cerebrospinal fluid, and brain tissue) to better understand brain blood vessel disease, its links to the immune system, and the combined effects on brain dysfunction, we hope to make breakthrough therapeutic discoveries that will help people at risk for or living with CADASIL and more common causes of brain vascular dysfunction in Alzheimer’s disease, frontotemporal dementias, and Parkinson’s disease and related disorders. We use multiple molecular and imaging tools and advanced analytical methods such as AI/ML for discovery of treatments for brain vascular degenerative diseases.
