From dark horse to front-runner: Vascular contributions to brain health

Gupta A, Pires PW, Billinger SA, Carmichael ST, Cortes CJ, Daneman R, Hu X, Kaufer D, Levendovszky SR, Sorond FA, Stillman CM, Tarantini S, Wilcock DM, Williamson JD, Yabluchanskiy A, Elahi FM, Zuloaga KL (2025) Geroscience

Cognitive impairment and p-tau217 are high in a vascular patient cohort

French SR, Arias JC, Zahra S, Ally M, Escareno C, Heitkamp E, Vazquez F, Hillis M, Wiskoski H, Ainapurapu K, Culwell G, Howell C, Johnson K, Kraemer C, Pacanowski J, Leon L, Berman S, Yanquez F, Balderman J, Sabat J, Hung O, Lucas L, Vitali F, Bedrick EJ, Mushtaq R, Altbach M, Trouard TP, Elahi FM, Ashton NJ, Dage JL, Reiman EM, Alexander GE, Weinkauf CC (2025) Alzheimer’s & Dementia

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD

Clelland CD, Fan L, Saloner R, Etchegaray JI, Altobelli CR, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee SI, Li Y, Zhou Y, Le D, Wang C, Carling G, Kodama L, Sayed F, Perez-Bermejo JA, Geier EG, Yokoyama JS, Rosen H, Nana AL, Spina S, Grinberg LT, Seeley WW, Elahi FM, Boxer AL, Arkin MR, Gan L (2025) Communications Biology

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

Frost B, Rowe JB, Akinyemi RO, Abisambra JF, Ashton NJ, Brendel M, Buée L, Butler D, Carrillo MC, Chung P, Clelland CD, DeVos SL, Diaz K, Edelmayer RM, Elahi FM, Ellajosyula R, Ewen C, Fontana IC, Galas MC, Hansson O, Höglinger G, Horie K, Ibanez A, Jacobs L, Maina MB, Malpetti M, McDade E, McEwan W, Montoliu-Gaya L, Mummery CJ, Orr ME, Rohrer JD, Rommel A, Sastre C, Spires-Jones TL, Tee BL, Viney TJ, Walker JM, Wegmann S, Wildsmith K, Yadav R, Mahinrad S, Sexton C (2025) Alzheimer’s & Dementia

Machine learning for missing data imputation in Alzheimer’s research: Predicting medial temporal lobe flexibility

Moallemian S, Saghafi A, Deshpande R, Perez JM, Budak M, Fausto BA, Elahi FM, Gluck MA (2025) bioRxiv

Integrating microfluidic and bioprinting technologies: advanced strategies for tissue vascularization

Mei X,Yang Z, Wang X, Shi A, Blanchard J, Elahi FM, Kang H, Orive G, Zhang YS (2025) Lab on a Chip.

White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status

Kern KC, Vohra M, Thirion ML, Wang DJJ, Wilcock DM, Thompson JF, Rosenberg GA, Sagare A, Moghekar A, Lu H, Lee T, Elahi FM, Satizabal CL, Tracy R, Seshadri S, Schwab K, Helmer K, Singh H, Kivisäkk P, Greenberg SM, Vossel K, Kramer JH, Maillard P, DeCarli CS, Hinman JD (2025) Alzheimer’s & Dementia

Sexually dimorphic differences in angiogenesis markers are associated with brain aging trajectories in humans

Torres-Espin A, Radabaugh H, Treiman S, Fitzsimons SS, Harvey D, Chou A, Lindbergh CA, Casaletto KB, Goldberger L, Staffaroni AM, Maillard P, Miller BL, DeCarli C, Hinman JD, Ferguson AR, Kramer JH, Elahi FM (2024) Science Translational Medicine.

The promise of molecular science in brain health. What breakthroughs are anticipated in the next 20 years?

Hainsworth AH, Blackburn TP, Bradshaw EM, Elahi FM, Gorelick PB, Isaacs JD, Wallin A, Williams SCR (2024) Cerebral Circulation - Cognition and Behavior

Neurovascular coupling, functional connectivity and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment

Owens CD, Pinto CB, Mukli P, Gulej R, Velez FS, Detwiler S, Olay L, Hoffmeister JR, Szarvas Z, Muranyi M, Peterfi A, Pinaffi-Langley ACC, Adams C, Sharps J, Kaposzta Z, Prodan CI, Kirkpatrick A, Tarantini S, Csiszar A, Ungvari Z, Olson A, Li G, Balasubramanian P, Galvan V, Bauer A, Smith ZA, Dasari TW, Whitehead S, Medapti MR, Elahi FM, Thanou A, Yabluchanskiy A (2024) Alzheimer’s & Dementia

Examining associations between smartphone use and clinical severity in frontotemporal dementia: Proof-of-concept study

Paolillo EW, Casaletto KB, Clark AL, Taylor JC, Heuer HW, Wise AB, Dhanam S, Sanderson-Cimino M, Saloner R, Kramer JH, Kornak J, Kremers W, Forsberg L, Appleby B, Bayram E, Bozoki A, Brushaber D, Darby R, Day GS, Dickerson BC, Domoto-Reilly K, Elahi FM, Fields JA, Ghoshal N, Graff-Radford N, Hall MGH, Honig LS, Huey ED, Lapid MI, Litzan I, Mackenzie IR, Masdeu JC, Mendez MF, Mester C, Miyagawa T, Naasan G, Pascual B, Pressman P, Ramos EM, Rankin KP, Rexach J, Rojas JC, VandeVrede L, Wong B, Wszolek ZK, Boeve BF, Rosen HJ, Boxer Al, Staffaroni AM (2024) Journal of Medical Internet Research

Small RNA signatures of acute ischemic stroke in L1CAM positive extracellular vesicles

Manwani B, Brathaban N, Baqai A, Munshi Y, Ahnstedt HW, Zhang M, Arkelius K, Llera T, Amorim E, Elahi FM, Singhal NS (2024) Scientific Reports

Linking peripheral atherosclerosis to blood–brain barrier disruption: elucidating its role as a manifestation of cerebral small vessel disease in vascular cognitive impairment

Nyúl-Tóth Á, Patai R, Csiszar A, Ungvari A, Gulej R, Mukli P, Yabluchanskiy A, Benyo Z, Sotonyi P, Prodan CI, Liotta EM, Toth P, Elahi FM, Barsi P, Maurovich-Horvat P, Sorond FA, Tarantini S, Ungvari Z (2024) GeroScience

Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia

Tan LX, Oertel FC, Cheng A, Cobigo Y, Keihani A, Bennett DJ, Abdelhak A, Montes SC, Chapman M, Chen RY, Cordano C, Ward ME, Casaletto K, Kramer JH, Rosen HJ, Boxer A, Miller BL, Green AJ, Elahi FM*, Lakkaraju A* (2024) bioRxiv

Vascular Cognitive Impairment

Windon C, Elahi FM, In: Ovbiagele B, Kim AS (eds) (2024) Ischemic Stroke Therapeutics

Plasma proteomics of genetic brain arteriosclerosis and dementia syndrome identifies signatures of fibrosis, angiogenesis, and metabolic alterations

Keller JN, Radabaugh H, Karvelas N, Fitzsimons S, Treiman S, Palafox MF, McDonnell L, Quiroz YT, Lopera FJ, Banerjee D, Wang MM, Arboleda-Velasquez JF, Meschia JF, Ferguson AR, Elahi FM (2024) bioRxiv

Enlarged perivascular spaces are associated with white matter injury, cognition and inflammation in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Karvelas N, Oh B, Wang E, Cobigo Y, Tsuei T, Fitzsimons S, Younes K, Ehrenberg A, Geschwind MD, Schwartz D, Kramer JH, Ferguson AR, Miller BL, Silbert LC, Rosen HJ, Elahi FM (2024) Brain Communications

Proteomic profiling of intracranial atherosclerotic plaque in the human brain

Hao Q, Wang E, Wang J, Wu Z, Crary JF, Sharma S, Thorn EL, Elahi FM, Zhang B, Peng J (2024) bioRxiv

Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer’s disease: Opportunities for therapy

Kelly L, Brown C, Michalik D, Hawkes CA, Aldea R, Agarwal N, Salib R, Alzetani A, Ethell DW, Counts SE, de Leon M, Fossati S, Koronyo-Hamaoui M, Piazza F, Rich SA, Wolters FJ, Snyder H, Ismail O, Elahi F, Proulx ST, Verma A, Wunderlich H, Haack M, Dodart JC, Mazer N, Carare RO (2023) Alzheimer's & Dementia

Management of inherited CNS small vessel diseases: the CADASIL example: a scientific statement from the American Heart Association

Meschia JF, Worrall BB, Elahi FM, Ross OA, Wang MM, Goldstein ED, Rost NS, Majersik JJ, Gutierrez J; on behalf of the American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Hypertension (2023) Stroke